RESOLVING DECONVOLUTION AMBIGUITY IN GENE ALTERNATIVE SPLICING

Resolving deconvolution ambiguity in gene alternative splicing

Abstract Background For many gene structures it is impossible to resolve intensity data uniquely to establish abundances of splice variants.This was empirically noted by Wang et al.in which it was called a "degeneracy problem".The ambiguity results from an ill-posed problem where additional information is needed in order to obtain an unique answer

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Diagnostic Role of Chromosomal Instability in Melanoma

Early diagnosis gives melanoma patients the best chance for long term survival.However discrimination of an early melanoma Cutting boards from an unusual/atypical benign nevus can represent a significant challenge.There are no current pathological markers to definitively define malignant potential in these indeterminate lesions.Thus, there is a nee

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Developments in the Understanding and Modeling of the Agglomeration of Suspended Crystals in Crystallization from Solutions

The paper deals with the modeling of the agglomeration of crystals during their crystallization.Crystal agglomeration actually consists of two steps, i.e.particle collision and agglomerate strengthening by crystal growth.The expression of agglomeration rates can be written in terms of a collision rate coupled with an efficiency factor.However, the

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